FDA Approves Drug for Obese Dogs

The U.S Food and Drug Administration (FDA) has announced the approval of Slentrol (dirlotapide), a prescription drug for the management of obesity in dogs. Slentrol reduces appetite and fat absorption to produce weight loss. A veterinarian will determine whether the dog should be treated, based on the dog's weight and general health.

"This is a welcome addition to animal therapies, because dog obesity appears to be increasing," said Stephen Sundlof, D.V.M., Ph.D., director of FDA's Center for Veterinary Medicine. "Veterinarians are well aware that overweight pets are at a higher risk of developing various health problems, from cardiovascular conditions to diabetes to joint problems."

Veterinarians generally define a dog that weighs 20% more than its ideal weight as obese. Surveys have found that approximately 5 percent of dogs in the United States are obese, and another 20-30 percent are overweight. The statistics are similar in the U.K.

Slentrol is a new chemical entity, called a selective microsomal triglyceride transfer protein inhibitor, which blocks the assembly and release of lipoproteins into the bloodstream. The mechanism for producing weight loss is not completely understood, but seems to result from reduced fat absorption and a satiety signal from lipid-filled cells lining the intestine.

The drug is given to the dog in varying amounts over the course of the treatment. The dog is given an initial dose for the first 14 days. After that, the veterinarian will assess the dog's progress at monthly intervals, adjusting the dose depending on the dog's weight loss. After the dog has achieved the goal weight, the drug's manufacturer recommends continued use of the drug during a three-month period, while the veterinarian and dog owner establish the optimal level of food intake and physical activity needed to maintain the dog's weight.

Adverse reactions associated with treatment with Slentrol include vomiting, loose stools, diarrhoea, lethargy and loss of appetite.

To discourage human use, the label of Slentrol includes the standard warning,

"Not for use in humans. Keep this and all drugs out of reach of children,"

and cites adverse reactions associated with human use, including abdominal distention, abdominal pain, diarrhoea, flatulence, headache, nausea and vomiting.

At PetClub UK, we believe the best form of medicine is the prevention of obesity rather than the treatment. Regular daily exercise along with a good, natural and balanced diet is the key to success. Treats should be given sparingly, and only as a reward for good behaviour.

Overweight or obese dogs can also try a 'light' diet. Berrimans Senior / Light Plus is designed specifically for older or overweight dogs which are fairly inactive.

To voice your opinions on this matter, join our discussion here.

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